ParkinsonFranceV1, Main, Exploration, bibRecord, 001869

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.

Identifieur interne : 001869 ( Main/Exploration ); précédent : 001868; suivant : 001870

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.

Auteurs : Peter A. Tass [Allemagne] ; Li Qin [États-Unis] ; Christian Hauptmann [Allemagne] ; Sandra Dovero [France] ; Erwan Bezard [France] ; Thomas Boraud [France] ; Wassilios G. Meissner [France]

Source :

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference [ 1557-170X ] ; 2010-11-30.

RBID : Hal:hal-01290749

Abstract

Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson's disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primates have set the grounds for its successful translation to PD patients. Since then, this model has allowed gaining significant insights in the underlying mechanisms of action of DBS and is currently being used for the development of new stimulation techniques. Altogether, this underpins the high potential of this preclinical model for future translation of DBS research in PD.

Url:

https://hal.archives-ouvertes.fr/hal-01290749

DOI: 10.1109/IEMBS.2011.6090148

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000B51
to stream Hal, to step Curation: 000B51
to stream Hal, to step Checkpoint: 000622
to stream Main, to step Merge: 001971
to stream Main, to step Curation: 001869

Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson's disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primates have set the grounds for its successful translation to PD patients. Since then, this model has allowed gaining significant insights in the underlying mechanisms of action of DBS and is currently being used for the development of new stimulation techniques. Altogether, this underpins the high potential of this preclinical model for future translation of DBS research in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
</region>
<settlement><li>Bordeaux</li>
</settlement>
<orgName><li>Université de Bordeaux</li>
</orgName>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A" last="Tass">Peter A. Tass</name>
</noRegion>
<name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Qin, Li" sort="Qin, Li" uniqKey="Qin L" first="Li" last="Qin">Li Qin</name>
</noRegion>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name>
</region>
<name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<name sortKey="Boraud, Thomas" sort="Boraud, Thomas" uniqKey="Boraud T" first="Thomas" last="Boraud">Thomas Boraud</name>
<name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.

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